Multi-level profiling of the Fmr1 KO rat unveils alteredbehavioral traits along with aberrant glutamatergic function
Fragile X syndrome (FXS) is the most common cause of inherited intellectual disabilities and the most prevalent monogenic cause of autism. Although the knockout (KO) of the Fmr1 gene homolog in mice is primarily used for elucidating the neurobiological substrate of FXS, there is limited association of the experimental data with the pathophysiological condition in […]
Cognitive impairment and alterations in glutamatergic function of Fmr1KO rats
Παρουσίαση του PowerPoint Adult male Fmr1 KO and WT littermates were used. Motor activity and habituation were estimated as well as recognition and spatial memory with NORT and NOLT. NMDA and AMPA subunits protein expression were evaluated in the prefrontal cortex (PFC) and Hippocampus (HIPP) using Western blot analyses. In parallel, glutamate (Glu), glutamine (GLN) […]
