Neuroplasticity profile and neurogenic activity in Fmr1

Fragile X Syndrome (FXS) is a neurodevelopmental disorder with autism like symptomatology that is caused by the loss of Fragile X Mental Retardation protein (FMRP). This lack leads to dysregulation of synaptic plasticity and cognitive deficits. In the present study we evaluated the biophenotype of Fmr1KO and wildtype (WT) rats using specific behavioral tasks that are related to cognitive functions along with neuroplasticity and neurogenesis indices.