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Λίστα ανακοινώσεων & δημοσιεύσεων του έργου
ΤΙΤΛΟΣ ΕΡΓΟΥ: Προκλινικός έλεγχος της αποτελεσματικότητας αγωνιστών και ανταγωνιστών του ενδοκανναβινοειδούς συστήματος σε ζωικό μοντέλο αυτισμού – Επίμυς Fmr1 KO
ΚΩΔΙΚΟΣ ΕΡΓΟΥ: Τ2ΕΔΚ-02075
ΕΠΙΣΤΗΜΟΝΙΚΑ ΥΠΕΥΘΥΝΗ: Αντωνίου Αικατερίνη, Καθηγήτρια Φαρμακολογίας, Εργαστήριο Φαρμακολογίας, Ιατρικό Τμήμα, Σχολή Επιστημών Υγείας, Πανεπιστήμιο Ιωαννίνων
ΦΟΡΕΑΣ: ΕΚΠΑ – ΕΕ2
AΝΑΚΟΙΝΩΣΕΙΣ
- Maria C. Kalaboka, Petros S. Tzimas, George Ntoulas, Alexia Polissidis, Eleftherios A. Petrakis, Maria Halabalaki, Leandros A. Skaltsounis (2022). Integrating analytical methods for endocannabinoid system exploration: Determination of endogenous and plant cannabinoids in relevant matrices. 70th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 28-31 August, Thessaloniki, Greece. Planta Medica 2022; 88 (15): 1451. DOI: 10.1055/s-0042-1759039.
ΔΗΜΟΣΙΕΥΣΕΙΣ
- Tzimas PS, Petrakis EA, Halabalaki M, Skaltsounis LA (2023). Extraction solvent selection for Cannabis sativa by efficient exploration of cannabinoid selectivity and phytochemical diversity. Η εν λόγω εργασία έχει υποβληθεί επιτυχώς στο διεθνές περιοδικό με συντελεστή απήχησης «Phytochemical Analysis», (υπό κρίση), (συντελεστής απήχησης: 5.5).
ΦΟΡΕΑΣ: ΠΙ – ΕΕ3
AΝΑΚΟΙΝΩΣΕΙΣ
- Ntoulas George, Brakatselos Charalambos., Asprogerakas Michalis-Zois. ,Nakas Gerasimos., Kokras Nikolaos , Polissidis Alexia, Dalla Christina, Antoniou Katerina. “Cognitive impairment and alterations of glutamatergic function of Fmr1KO rats, an animal model of the Fragile X Syndrome.” 8th Mediterranean Neuroscience Society (MNS), May 29- June 2 2022. Dubrovnik, Croatia
- Ntoulas G. , Brakatselos C. , Asprogerakas M. ,Nakas G. , Kokras N , Polissidis A. , Dalla C. , Antoniou K. “Alterations in Glutamatergic function of Fmr1 knock out rats, an animal model of autism spectrum disorders.” 15th European Association for Clinical Pharmacology and Therapeutics 25-28 June 2022. Athens, Greece.
- Ntoulas G. , Brakatselos C. , Asprogerakas M. ,Nakas G. , Tsarna O. , Antoniou K. “Neuroplasticity profile and neurogenic activity in Fmr1 Knock out rats, a model of Fragile X Syndrome. “FENS FORUM 2022, 9-13 July 2022. Paris, France.
- Ntoulas G., Brakatselos C. , Asprogerakas M., Nakas G., Tsarna O., Gkikas D., Polissidis A., Koutmani Y. , Politis P.K., Antoniou K. “Profiling Fragile X Syndrome on neuroplasticity indices, cognitive function, and the endocannabinoid system through an animal model.’’ 35th ECNP Congress, 15-18 October 2022, Vienna, Austria.
- Ntoulas George , Nakas Gerasimos , Brakatselos Charalambos, Asprogerakas Michalis-Zois. , Kokras Nikolaos, Dalla Christina, Petros S. Tzimas, Maria Halabalaki, Polissidis Alexia. Antoniou Katerina, “Modulatory Effects of Cannabidiol on the Behavioral and Neurobiological Alterations in a Rat Model of Fragile X Syndrome.” 9th Mediterranean Neuroscience Society (MNS), 14-18 October 2023, Tunisia.
ΔΗΜΟΣΙΕΥΣΕΙΣ
- Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Ntoulas G, Brakatselos C, Nakas G, Asprogerakas MZ, Delis F, Leontiadis LJ, Trompoukis G, Papatheodoropoulos C, Gkikas D, Valakos D, Vatsellas G, Politis PK, Polissidis A, Antoniou K.Transl Psychiatry. 2024 Feb 20;14(1):104. doi: 10.1038/s41398-024-02815-0
ΠΠ – ΕΕ4
AΝΑΚΟΙΝΩΣΕΙΣ
- Προσκεκλημένη Ομιλία στην Διεθνή Συνάντηση για τον Ιππόκαμπο: “Spring Hippocampal Research Conference”, 2023, Verona, Italy. “Dorsoventral differences in short-term neuronal dynamics in the hippocampus of a rat model of fragile X syndrome” by Tsotsokou G.
- Miliou A, G Trompoukis and C Papatheodoropoulos . Increased ability for b-adrenergic receptor induced LTP in the dorsal compared with ventral Hippocampus. FENS Regional Meeting, 3-5 May 2023, Algarve Portugal.
ΔΗΜΟΣΙΕΥΣΕΙΣ
- Samara M, Oikonomou GD, Trompoukis G, Madarou G, Adamopoulou M, Papatheodoropoulos C (2022), Septotemporal variation in modulation of synaptic transmission, paired-pulse ratio and frequency facilitation/depression by adenosine and GABA(B) receptors in the rat hippocampus. Brain and neuroscience advances 6:23982128221106315. (συντελεστής απήχησης: 14)
- Trompoukis G, Leontiadis LJ, Rigas P, Papatheodoropoulos C (2021), Scaling of Network Excitability and Inhibition may Contribute to the Septotemporal Differentiation of Sharp Waves-Ripples in Rat Hippocampus In Vitro. Neuroscience 458:11-30. (συντελεστής απήχησης: 7)
ΙΙΒΕΑΑ – ΕΕ5
AΝΑΚΟΙΝΩΣΕΙΣ
- Dimitrios Gkikas, Dimitris Stellas, Alexia Polissidis, Maroula Kokotou, George Kokotos and Panagiotis K. Politis. NR5A2 as a potential drug target in Glioblastoma FENS Forum 2022, , 9-13 July 2022, Paris, France
ΔΗΜΟΣΙΕΥΣΕΙΣ
- Matina Tsampoula, Isaak Tarampoulous, Theodora Manolakou, Elpinickie Ninou, Panagiotis K Politis. The Neurodevelopmental Disorders Associated Gene Rnf113a Regulates Survival and Differentiation Properties of Neural Stem Cells. Stem Cells, 2022, 40, 678–690, https://doi.org/10.1093/stmcls/sxac030. (συντελεστής απήχησης: 5.84)
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Multi-level profiling of the Fmr1 KO rat unveils alteredbehavioral traits along with aberrant glutamatergic function
Fragile X syndrome (FXS) is the most common cause of inherited intellectual disabilities and the most prevalent monogenic cause of autism. Although the knockout (KO)

Διερευνώντας τη νευροφυσιολογία της νοητικής υστέρησης/αυτισμού
Μια βασική πρόκληση της νευροεπιστήμης είναι ο εντοπισμός νευροβιολο- γικών φαινομένων, τα οποία δύ- νανται να χαρακτηρίζουν με εξει- δικευμένο τρόπο γνωσιακές και νευροψυχιατρικές καταστάσεις

Cognitive impairment and alterations in glutamatergic function of Fmr1KO rats
Παρουσίαση του PowerPoint Adult male Fmr1 KO and WT littermates were used. Motor activity and habituation were estimated as well as recognition and spatial memory

Neuroplasticity profile and neurogenic activity in Fmr1
Fragile X Syndrome (FXS) is a neurodevelopmental disorder with autism like symptomatology that is caused by the loss of Fragile X Mental Retardation protein (FMRP).